Objective To investigate the current status of infusion of vasoactive agents of Chinese nurses and compare the differences between different hospitals. Methods Convenience sampling method was used to conduct a descriptive online survey in 31 provinces from July to August,2020. The contents of the survey include demographic characteristics,current application of vasoactive agents,the use of vascular access and nursing practice of vasoactive agent infusion. Results A total of 7 873 qualified samples were collected. Indwelling needles(93.92%)were the most common vascular access for vasoactive agent,followed by central venous catheters(61.27%),and steel needles accounted for the least(15.11%). The proportion of nurses in tertiary hospitals or cardiovascular specialist hospitals using central venous catheters was relatively higher than that in non-tertiary hospitals or general hospitals(P<0.001). Blood pressure,heart rate and respiration rate were 3 commonly used indicators for both evaluation and observation. Compared with the nurses in tertiary hospitals,there is a relatively higher proportion of nurses in non-tertiary hospitals who do not change the infusion site,use adjustable infusion apparatus or manual speed control,think that changing the height of syringe pumps does not affect the stability of the infusion,do not pump back before locking,press quick infusion key or make a rapid injection of normal saline when the blood returns,and do not perform ECG monitoring for all patients when infusing vasoactive agents(P<0.05). Meanwhile,there is a higher proportion of nurses in general hospitals who inject other agents fleetly through T-pipe,do not pump back before locking,press quick infusion key or rapid inject normal saline when blood returns and do not perform ECG monitoring for all patients when infusing vasoactive agents,compared with nurses in cardiovascular specialist hospitals(P<0.001). Conclusion The nursing practice of infusing vasoactive agents has safety risks. Thus,the nursing standards for intravenous infusion of vasoactive agents need to be revised,and nurse managers are advised to conduct standardized management and supervision.